In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous ...

Multicellularity is one of the most profound phenomena in biology, and relies on the ability of a single cell to reorganize itself into a complex organism. It underpins the diversity in the animal ...

Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations involving the NPM gene cause ...

Immune checkpoints are regulatory proteins that prevent the immune system from attacking healthy tissues. Some cancer cells exploit these checkpoints to avoid immune detection. Immune checkpoint ...

The current coronavirus disease 2019 (COVID-19) pandemic has claimed over 1.9 million lives so far, and scientists have been racing to develop vaccines that will curtail its spread. Most of these ...

In preparation of an upcoming neoadjuvant study investigating iniparib in combination with various taxane-based chemotherapies, we have evaluated the prevalence of PARP expression in various subtypes ...

One characteristic of oocyte development and physiology that has been a mystery for 60 years is the highly present cytoplasmic lattices within the cytoplasm of mammalian oocytes. These were initially ...

A phase Ia/Ib study of talazoparib in combination with tazemetostat in metastatic castration-resistant prostate cancer (mCRPC).